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Title:

Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Gottschalk, Catherine; Damuzzo, Vera; Gotot, Janine; Kroczek, Richard A; Yagita, Hideo; Murphy, Kenneth M; Knolle, Percy A; Ludwig-Portugall, Isis; Kurts, Christian
Abstract:
Although the spleen is a major site where immune tolerance to circulating innocuous antigens occurs, the kidney also contributes. Circulating antigens smaller than albumin are constitutively filtered and concentrated in the kidney and reach the renal lymph node by lymphatic drainage, where resident dendritic cells (DCs) capture them and induce tolerance of specific cytotoxic T cells through unknown mechanisms. Here, we found that the coinhibitory cell surface receptor programmed death 1 (PD-1) o...     »
Journal title abbreviation:
J Am Soc Nephrol
Year:
2013
Journal volume:
24
Journal issue:
4
Pages contribution:
543-9
Language:
eng
Fulltext / DOI:
doi:10.1681/ASN.2012101022
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23411785
Print-ISSN:
1046-6673
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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