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Title:

Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Böttcher, Jan P; Schanz, Oliver; Wohlleber, Dirk; Abdullah, Zeinab; Debey-Pascher, Svenja; Staratschek-Jox, Andrea; Höchst, Bastian; Hegenbarth, Silke; Grell, Jessica; Limmer, Andreas; Atreya, Imke; Neurath, Markus F; Busch, Dirk H; Schmitt, Edgar; van Endert, Peter; Kolanus, Waldemar; Kurts, Christian; Schultze, Joachim L; Diehl, Linda; Knolle, Percy A
Abstract:
Development of CD8(+) T cell (CTL) immunity or tolerance is linked to the conditions during T cell priming. Dendritic cells (DCs) matured during inflammation generate effector/memory T cells, whereas immature DCs cause T cell deletion/anergy. We identify a third outcome of T cell priming in absence of inflammation enabled by cross-presenting liver sinusoidal endothelial cells. Such priming generated memory T cells that were spared from deletion by immature DCs. Similar to central memory T cells,...     »
Journal title abbreviation:
Cell Rep
Year:
2013
Journal volume:
3
Journal issue:
3
Pages contribution:
779-95
Language:
eng
Fulltext / DOI:
doi:10.1016/j.celrep.2013.02.008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23499443
Print-ISSN:
2211-1247
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Roman Herzog Comprehensive Cancer Center
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