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Title:

Antiproliferative effects of selective adenosine receptor agonists and antagonists on human lymphocytes: evidence for receptor-independent mechanisms.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Schiedel, Anke C; Lacher, Svenja K; Linnemann, Carsten; Knolle, Percy A; Müller, Christa E
Abstract:
The effects of standard adenosine receptor (AR) agonists and antagonists on the proliferation of human T lymphocytes, unstimulated and phytohemagglutinin-stimulated human peripheral blood lymphocytes (PBL), and Jurkat T cells were investigated. Real-time PCR measurements confirmed the presence of all four AR subtypes on the investigated cells, although at different expression levels. A2A ARs were predominantly expressed in PBL and further upregulated upon stimulation, while malignant Jurkat T ce...     »
Journal title abbreviation:
Purinergic Signal
Year:
2013
Journal volume:
9
Journal issue:
3
Pages contribution:
351-65
Language:
eng
Fulltext / DOI:
doi:10.1007/s11302-013-9354-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23359122
Print-ISSN:
1573-9538
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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