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Titel:

Escherichia coli-induced immune paralysis is not exacerbated during chronic filarial infection.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Buerfent, Benedikt C; Gondorf, Fabian; Wohlleber, Dirk; Schumak, Beatrix; Hoerauf, Achim; Hübner, Marc P
Abstract:
Sepsis initially starts with a systemic inflammatory response (SIRS phase) and is followed by a compensatory anti-inflammatory response syndrome (CARS) that causes impaired adaptive T-cell immunity, immune paralysis and an increased susceptibility to secondary infections. In contrast, parasitic filariae release thousands of microfilariae into the peripheral blood without triggering inflammation, as they induce regulatory, anti-inflammatory host responses. Hence, we investigated the impact of chr...     »
Zeitschriftentitel:
Immunology
Jahr:
2015
Band / Volume:
145
Heft / Issue:
1
Seitenangaben Beitrag:
150-60
Sprache:
eng
Volltext / DOI:
doi:10.1111/imm.12435
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25521437
Print-ISSN:
0019-2805
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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