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Title:

B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Herold, Martin; Posevitz, Vilmos; Chudyka, Daria; Hucke, Stephanie; Groß, Catharina; Kurth, Frank; Leder, Christoph; Loser, Karin; Kurts, Christian; Knolle, Percy; Klotz, Luisa; Wiendl, Heinz
Abstract:
It is currently acknowledged that TH17 cells are critically involved in the pathogenesis of autoimmune diseases such as multiple sclerosis (MS). In this article, we demonstrate that signals delivered by the coinhibitory molecule B7-homologue 1 (B7-H1) via a B7-homologue 1 mouse-IgG2aFc (B7-H1-Ig) fusion protein nearly abolish TH17, but not TH1 and TH2, differentiation via direct interaction with the T cell. These effects were equally pronounced in the absence of programmed death-1 or B7.1 and B7...     »
Journal title abbreviation:
J Immunol
Year:
2015
Journal volume:
195
Journal issue:
8
Pages contribution:
3584-95
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.1402746
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26378076
Print-ISSN:
0022-1767
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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