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Title:

Differential induction of Ly6G and Ly6C positive myeloid derived suppressor cells in chronic kidney and liver inflammation and fibrosis.

Document type:
Journal Article; Article
Author(s):
Höchst, Bastian; Mikulec, Julita; Baccega, Tania; Metzger, Christina; Welz, Meike; Peusquens, Julia; Tacke, Frank; Knolle, Percy; Kurts, Christian; Diehl, Linda; Ludwig-Portugall, Isis
Abstract:
CD11b+Gr1+ myeloid derived suppressor cells (MDSC) are known to be very potent suppressors of T cell immunity and can be further stratified into granulocytic MDSC and monocytic MDSC in mice based on expression of Ly6G or Ly6C, respectively. Here, using these markers and functional assays, we aimed to identify whether MDSC are induced during chronic inflammation leading to fibrosis in both kidney and liver and whether additional markers could more specifically identify these MDSC subsets. In an a...     »
Journal title abbreviation:
PLoS ONE
Year:
2015
Journal volume:
10
Journal issue:
3
Pages contribution:
e0119662
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0119662
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25738302
Print-ISSN:
1932-6203
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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