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Title:

IAP antagonization promotes inflammatory destruction of vascular endothelium.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Witt, Axel; Seeger, Jens M; Coutelle, Oliver; Zigrino, Paola; Broxtermann, Pia; Andree, Maria; Brinkmann, Kerstin; Jüngst, Christian; Schauss, Astrid C; Schüll, Stephan; Wohlleber, Dirk; Knolle, Percy A; Krönke, Martin; Mauch, Cornelia; Kashkar, Hamid
Abstract:
In this study, we show for the first time that the therapeutic antagonization of inhibitor of apoptosis proteins (IAPs) inhibits B16 melanoma growth by disrupting tumor vasculature. Specifically, the treatment of mice bearing B16 melanoma with an IAP antagonist compound A (Comp A) inhibits tumor growth not by inducing direct cytotoxicity against B16 cells but rather by a hitherto unrecognized antiangiogenic activity against tumor vessels. Our detailed analysis showed that Comp A treatment induce...     »
Journal title abbreviation:
EMBO Rep
Year:
2015
Journal volume:
16
Journal issue:
6
Pages contribution:
719-27
Language:
eng
Fulltext / DOI:
doi:10.15252/embr.201439616
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25825408
Print-ISSN:
1469-221X
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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