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Title:

The role of hepatic immune regulation in systemic immunity to viral infection.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review; Review
Author(s):
Knolle, Percy A; Böttcher, Jan; Huang, Li-Rung
Abstract:
The liver has particular immune functions attributed by its unique microenvironment and its liver-resident cell populations. During autoimmunity and viral hepatitis, the liver serves as target for effector responses of immune cells. However, skewing of effector T cell functions through tolerogenic liver-resident antigen-presenting cells and through the immune regulatory hepatic microenvironment. Importantly, the liver also participates in shaping systemic antigen-specific immunity. Local antigen...     »
Journal title abbreviation:
Med Microbiol Immunol (Berl)
Year:
2015
Journal volume:
204
Journal issue:
1
Pages contribution:
21-7
Language:
eng
Fulltext / DOI:
doi:10.1007/s00430-014-0371-0
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25523194
Print-ISSN:
0300-8584
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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