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Titel:

B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Herold, Martin; Posevitz, Vilmos; Chudyka, Daria; Hucke, Stephanie; Groß, Catharina; Kurth, Frank; Leder, Christoph; Loser, Karin; Kurts, Christian; Knolle, Percy; Klotz, Luisa; Wiendl, Heinz
Abstract:
It is currently acknowledged that TH17 cells are critically involved in the pathogenesis of autoimmune diseases such as multiple sclerosis (MS). In this article, we demonstrate that signals delivered by the coinhibitory molecule B7-homologue 1 (B7-H1) via a B7-homologue 1 mouse-IgG2aFc (B7-H1-Ig) fusion protein nearly abolish TH17, but not TH1 and TH2, differentiation via direct interaction with the T cell. These effects were equally pronounced in the absence of programmed death-1 or B7.1 and B7...     »
Zeitschriftentitel:
J Immunol
Jahr:
2015
Band / Volume:
195
Heft / Issue:
8
Seitenangaben Beitrag:
3584-95
Sprache:
eng
Volltext / DOI:
doi:10.4049/jimmunol.1402746
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26378076
Print-ISSN:
0022-1767
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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