Benutzer: Gast  Login
Titel:

IAP antagonization promotes inflammatory destruction of vascular endothelium.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Witt, Axel; Seeger, Jens M; Coutelle, Oliver; Zigrino, Paola; Broxtermann, Pia; Andree, Maria; Brinkmann, Kerstin; Jüngst, Christian; Schauss, Astrid C; Schüll, Stephan; Wohlleber, Dirk; Knolle, Percy A; Krönke, Martin; Mauch, Cornelia; Kashkar, Hamid
Abstract:
In this study, we show for the first time that the therapeutic antagonization of inhibitor of apoptosis proteins (IAPs) inhibits B16 melanoma growth by disrupting tumor vasculature. Specifically, the treatment of mice bearing B16 melanoma with an IAP antagonist compound A (Comp A) inhibits tumor growth not by inducing direct cytotoxicity against B16 cells but rather by a hitherto unrecognized antiangiogenic activity against tumor vessels. Our detailed analysis showed that Comp A treatment induce...     »
Zeitschriftentitel:
EMBO Rep
Jahr:
2015
Band / Volume:
16
Heft / Issue:
6
Seitenangaben Beitrag:
719-27
Sprache:
eng
Volltext / DOI:
doi:10.15252/embr.201439616
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25825408
Print-ISSN:
1469-221X
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
 BibTeX