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Titel:

Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Lang, P A; Meryk, A; Pandyra, A A; Brenner, D; Brüstle, A; Xu, H C; Merches, K; Lang, F; Khairnar, V; Sharma, P; Funkner, P; Recher, M; Shaabani, N; Duncan, G S; Duhan, V; Homey, B; Ohashi, P S; Häussinger, D; Knolle, P A; Honke, N; Mak, T W; Lang, K S
Abstract:
During virus infection and autoimmune disease, inflammatory dendritic cells (iDCs) differentiate from blood monocytes and infiltrate infected tissue. Following acute infection with hepatotropic viruses, iDCs are essential for re-stimulating virus-specific CD8(+) T cells and therefore contribute to virus control. Here we used the lymphocytic choriomeningitis virus (LCMV) model system to identify novel signals, which influence the recruitment and activation of iDCs in the liver. We observed that i...     »
Zeitschriftentitel:
Cell Death Differ
Jahr:
2015
Band / Volume:
22
Heft / Issue:
1
Seitenangaben Beitrag:
164-73
Sprache:
eng
Volltext / DOI:
doi:10.1038/cdd.2014.138
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25257173
Print-ISSN:
1350-9047
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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