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Titel:

Differential induction of Ly6G and Ly6C positive myeloid derived suppressor cells in chronic kidney and liver inflammation and fibrosis.

Dokumenttyp:
Journal Article; Article
Autor(en):
Höchst, Bastian; Mikulec, Julita; Baccega, Tania; Metzger, Christina; Welz, Meike; Peusquens, Julia; Tacke, Frank; Knolle, Percy; Kurts, Christian; Diehl, Linda; Ludwig-Portugall, Isis
Abstract:
CD11b+Gr1+ myeloid derived suppressor cells (MDSC) are known to be very potent suppressors of T cell immunity and can be further stratified into granulocytic MDSC and monocytic MDSC in mice based on expression of Ly6G or Ly6C, respectively. Here, using these markers and functional assays, we aimed to identify whether MDSC are induced during chronic inflammation leading to fibrosis in both kidney and liver and whether additional markers could more specifically identify these MDSC subsets. In an a...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2015
Band / Volume:
10
Heft / Issue:
3
Seitenangaben Beitrag:
e0119662
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0119662
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25738302
Print-ISSN:
1932-6203
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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