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- Original title:
- The regulation of Hsp90 by its essential co-chaperone Cns1
- Translated title:
- Die Regulation von Hsp90 durch das essentielle Co-Chaperon Cns1
- Author:
- Schopf, Florian Helmut
- Year:
- 2016
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Chemie
- Advisor:
- Buchner, Johannes (Prof. Dr.)
- Referee:
- Buchner, Johannes (Prof. Dr.); Feige, Matthias J. (Prof. Dr.); Freeman, Brian C. (Prof., Ph.D.)
- Language:
- en
- Subject group:
- CHE Chemie; CIT Chemie-Ingenieurwesen, Technische Chemie, Biotechnologie
- TUM classification:
- CHE 800d; CIT 900d
- Abstract:
- Hsp90 is an essential chaperone which is important for the folding and activation of many cellular proteins. It is regulated by a cohort of helper proteins, named co-chaperones. One of them is the essential protein Cns1. In this work, the minimal Cns1 domain required for viability was identified, the binding to and modulation of Hsp90 were investigated and the protein was characterized structurally. These findings lead to a comprehensive understanding of the Cns1-Hsp90 chaperone system.
- Translated abstract:
- Hsp90 ist ein essentielles molekulares Chaperon, das an der Faltung und Aktivierung vieler zellulärer Proteine beteiligt ist. Es wird von einer Reihe von Co-Chaperonen reguliert. Eines davon ist das essentielle Protein Cns1. In dieser Arbeit wird die minimale Cns1-Domäne in vivo identifiziert, Bindung an und Modulation von Hsp90 werden untersucht und das Protein wird strukturell charakterisiert. Diese Resultate führen zu einem umfassenden Verständnis des Cns1-Hsp90 Chaperonsystems.
- WWW:
- https://mediatum.ub.tum.de/?id=1324343
- Date of submission:
- 25.08.2016
- Oral examination:
- 29.11.2016
- File size:
- 82141728 bytes
- Pages:
- 166
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20161129-1324343-1-6
- Last change:
- 28.11.2018
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