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Titel:

Modulating Mucin Hydration and Lubrication by Deglycosylation and Polyethylene Glycol Binding

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Crouzier, Thomas; Boettcher, Kathrin; Geonnotti, Anthony R.; Kavanaugh, Nicole L.; Hirsch, Julie B.; Ribbeck, Katharina; Lieleg, Oliver
Abstract:
A key property of mucin glycoproteins is their exceptional capacity to hydrate and lubricate surfaces. In vivo, mucins assemble into mucus hydrogels that cover the epithelium and protect it from dehydration and shear stress. A better understanding of the origin of these properties could lead to new treatment strategies for patients with poor mucus coverage, defective mucus production, or glycosylation as caused by Sjogren syndrome, dry eye, or in the case of certain bacterial infections. In this...     »
Stichworte:
PORCINE GASTRIC MUCIN; BOUNDARY LUBRICATION; MOLECULAR-WEIGHT; SHEAR FORCES; SURFACES; POLYMER; MUCUS; POLYELECTROLYTE; GLYCOPROTEIN; SUBMAXILLARY
Dewey Dezimalklassifikation:
500 Naturwissenschaften
Zeitschriftentitel:
Adv. Mater. Interfaces
Jahr:
2015
Heft / Issue:
18
Seitenangaben Beitrag:
n/a-n/a
Nachgewiesen in:
Web of Science
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1002/admi.201500308
WWW:
http://onlinelibrary.wiley.com/doi/10.1002/admi.201500308/abstract
Verlag / Institution:
Wiley-Blackwell
Print-ISSN:
2196-7350
Publikationsdatum:
24.09.2015
TUM Einrichtung:
Professur für Biomechanik
Format:
Bild/Text
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