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- Original title:
- Pharmakogenetische und pharmakodynamische Analysen der Clopidogrel-Wirkung bei Patienten mit koronarer Stentimplantation
- Translated title:
- Pharmacogenetic and pharmacodynamic analyses of the clopidogrel-effect in patients receiving coronary stents
- Author:
- Kappeler, Julia Christina
- Year:
- 2017
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Medizin
- Advisor:
- Sibbing, Dirk (Prof. Dr.)
- Referee:
- Sibbing, Dirk (Prof. Dr.); Laugwitz, Karl-Ludwig (Prof. Dr.)
- Language:
- de
- Subject group:
- MED Medizin
- Keywords:
- Clopidogrel, Stent-Thrombose, CYP2C19*2, Rebound-Effekt, Thrombozyten-Aggregationsmessung, Lichttransmissions-Aggregometrie, multiple electrode aggregometry
- Translated keywords:
- clopidogrel, stent thrombosis, CYP2C19*2, rebound-effect, platelet function test, light-transmission aggregometry, multiple electrode aggregometry
- TUM classification:
- MED 410d
- Abstract:
- Unter 2485 Stent-Patienten unter dualer Thrombozyten-Aggregationshemmung mit Aspirin und Clopidogrel erlitten CYP2C19*2-Träger signifikant häufiger Stent-Thrombosen, ST-Hebungsinfarkte und ischämische zerebrale Insulte als Wildtyp-Homozygote. An 69 Stent-Patienten zeigte sich über 8 Wochen durch wiederholte Thrombozyten-Aggregationsmessungen mittels Lichttransmissions-Aggregometrie und Multiple Electrode Aggregometrie kein Vorteil eines ausschleichenden versus abrupten Absetzens von Clopidogrel.
- Translated abstract:
- In 2485 patients receiving coronary stents under dual antiplatelet therapy with aspirin and clopidogrel carriers of the CYP2C19*2 allele suffered significantly more frequently under stent thrombosis, STEMI and ischaemic stroke than wildtype-homozygotes. In 69 Stent-Patients weekly platelet function tests over 8 weeks with light-transmission aggregometry and multiple electrode aggregometry showed no benefit of a tapering versus an abrupt cessation of clopidogrel treatment.
- WWW:
- https://mediatum.ub.tum.de/?id=1288871
- Date of submission:
- 16.02.2016
- Oral examination:
- 08.02.2017
- File size:
- 1458898 bytes
- Pages:
- 70
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20170208-1288871-1-5
- Last change:
- 07.04.2017
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