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Title:

Novel Slow- and Fast-Type Drug Release Round-Window Microimplants for Local Drug Application to the Cochlea: An Experimental Study in Guinea Pigs

Author(s):
Arnold, Wolfgang; Senn, Pascal; Hennig, Michael; Michaelis, Christiane; Deingruber, Kerstin; Scheler, Renate; Steinhoff, Hans-Joachim; Riphagen, Frits; Lamm, Kerstin
Abstract:
Novel drug release microimplants (0.8 × 1.14 mm; custom-made by Leiras, now Schering OY, Finland) of slow- and fast-release types containing either 0.9 mg beclomethasone or no drug at all were placed unilaterally onto the round-window membrane (RWM) of 45 guinea pigs for a maximum duration of 28 days. The following parameters were tested on days 1, 14 and 28 after implantation: threshold levels of beclomethasone in the perilymph of the scala tympani, auditory brain stem responses (ABR threshold...     »
Keywords:
Glucocorticoids; Corticosteroids; Evoked potentials; auditory; brain stem; Cytocochleogram; Round-window microimplant; Guinea pig cochlea
Journal title:
Audiology and Neuro-Otology
Year:
2005
Journal volume:
10
Journal issue:
1
Pages contribution:
53--63
Fulltext / DOI:
doi:10.1159/000082575
Publisher:
S. Karger AG
Publisher address:
Basel, Switzerland
Print-ISSN:
1421-9700
E-ISSN:
1421-9700
Notes:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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