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Title:

The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity.

Document type:
Review; Journal Article; Review
Author(s):
Böttcher, Jan P; Reis E Sousa, Caetano
Abstract:
Dendritic cells (DCs) are key orchestrators of immune responses. A specific DC subset, conventional type 1 DCs (cDC1s), has been recently associated with human cancer patient survival and, in preclinical models, is critical for the spontaneous rejection of immunogenic cancers and for the success of T cell-based immunotherapies. The unique role of cDC1 reflects the ability to initiate de novo T cell responses after migrating to tumor-draining lymph nodes, as well as to attract T cells, secrete cy...     »
Journal title abbreviation:
Trends Cancer
Year:
2018
Journal volume:
4
Journal issue:
11
Pages contribution:
784-792
Fulltext / DOI:
doi:10.1016/j.trecan.2018.09.001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30352680
Print-ISSN:
2405-8033
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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