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Title:

Network Analysis Identifies Drug Targets and Small Molecules to Modulate Apoptosis Resistant Cancers.

Document type:
Article; Journal Article
Author(s):
Fathima, Samreen; Sinha, Swati; Donakonda, Sainitin
Abstract:
Programed cell death or apoptosis fails to induce cell death in many recalcitrant cancers. Thus, there is an emerging need to activate the alternate cell death pathways in such cancers. In this study, we analyzed the apoptosis-resistant colon adenocarcinoma, glioblastoma multiforme, and small cell lung cancers transcriptome profiles. We extracted clusters of non-apoptotic cell death genes from each cancer to understand functional networks affected by these genes and their role in the induction o...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2021
Journal volume:
13
Journal issue:
4
Fulltext / DOI:
doi:10.3390/cancers13040851
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33670487
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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