Benutzer: Gast  Login
Titel:

Control of cell penetration enhancer shielding and endosomal escape-kinetics crucial for efficient and biocompatible siRNA delivery.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Malfanti, Alessio; Sami, Haider; Balasso, Anna; Marostica, Giulia; Arpac, Busra; Mastrotto, Francesca; Mantovani, Giuseppe; Cola, Elisa; Anton, Martina; Caliceti, Paolo; Ogris, Manfred; Salmaso, Stefano
Abstract:
Although cationic liposomes are efficient carriers for nucleic acid delivery, their toxicity often hampers the clinical translation. Polyethylene glycol (PEG) coating has been largely used to improve their stability and reduce toxicity. Nevertheless, it has been found to decrease the transfection process. In order to exploit the advantages of cationic liposomes and PEG decoration for nucleic acid delivery, liposomes decorated with tetraArg-[G-1]-distearoyl glycerol (Arg4-DAG) dendronic oligo-cat...     »
Zeitschriftentitel:
J Control Release
Jahr:
2023
Band / Volume:
363
Seitenangaben Beitrag:
101-113
Volltext / DOI:
doi:10.1016/j.jconrel.2023.09.022
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37722420
Print-ISSN:
0168-3659
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
 BibTeX