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Titel:

The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity.

Dokumenttyp:
Review; Journal Article; Review
Autor(en):
Böttcher, Jan P; Reis E Sousa, Caetano
Abstract:
Dendritic cells (DCs) are key orchestrators of immune responses. A specific DC subset, conventional type 1 DCs (cDC1s), has been recently associated with human cancer patient survival and, in preclinical models, is critical for the spontaneous rejection of immunogenic cancers and for the success of T cell-based immunotherapies. The unique role of cDC1 reflects the ability to initiate de novo T cell responses after migrating to tumor-draining lymph nodes, as well as to attract T cells, secrete cy...     »
Zeitschriftentitel:
Trends Cancer
Jahr:
2018
Band / Volume:
4
Heft / Issue:
11
Seitenangaben Beitrag:
784-792
Volltext / DOI:
doi:10.1016/j.trecan.2018.09.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30352680
Print-ISSN:
2405-8033
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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