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Title:

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Poeck, H; Bscheider, M; Gross, O; Finger, K; Roth, S; Rebsamen, M; Hannesschläger, N; Schlee, M; Rothenfusser, S; Barchet, W; Kato, H; Akira, S; Inoue, S; Endres, S; Peschel, C; Hartmann, G; Hornung, V; Ruland, J
Abstract:
Interleukin 1 beta (IL-1 beta) is a potent proinflammatory factor during viral infection. Its production is tightly controlled by transcription of Il1b dependent on the transcription factor NF-kappaB and subsequent processing of pro-IL-1 beta by an inflammasome. However, the sensors and mechanisms that facilitate RNA virus-induced production of IL-1 beta are not well defined. Here we report a dual role for the RNA helicase RIG-I in RNA virus-induced proinflammatory responses. Whereas RIG-I-media...     »
Journal title abbreviation:
Nat Immunol
Year:
2010
Journal volume:
11
Journal issue:
1
Pages contribution:
63-9
Language:
eng
Fulltext / DOI:
doi:10.1038/ni.1824
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19915568
Print-ISSN:
1529-2908
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Roman Herzog Comprehensive Cancer Center
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