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Titel:

NK cells with tissue-resident traits shape response to immunotherapy by inducing adaptive antitumor immunity.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Autor(en):
Kirchhammer, Nicole; Trefny, Marcel P; Natoli, Marina; Brücher, Dominik; Smith, Sheena N; Werner, Franziska; Koch, Victoria; Schreiner, David; Bartoszek, Ewelina; Buchi, Mélanie; Schmid, Markus; Breu, Daniel; Hartmann, K Patricia; Zaytseva, Polina; Thommen, Daniela S; Läubli, Heinz; Böttcher, Jan P; Stanczak, Michal A; Kashyap, Abhishek S; Plückthun, Andreas; Zippelius, Alfred
Abstract:
T cell-directed cancer immunotherapy often fails to generate lasting tumor control. Harnessing additional effectors of the immune response against tumors may strengthen the clinical benefit of immunotherapies. Here, we demonstrate that therapeutic targeting of the interferon-γ (IFN-γ)-interleukin-12 (IL-12) pathway relies on the ability of a population of natural killer (NK) cells with tissue-resident traits to orchestrate an antitumor microenvironment. In particular, we used an engineered adeno...     »
Zeitschriftentitel:
Sci Transl Med
Jahr:
2022
Band / Volume:
14
Heft / Issue:
653
Volltext / DOI:
doi:10.1126/scitranslmed.abm9043
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35857639
Print-ISSN:
1946-6234
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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