Benutzer: Gast  Login
Titel:

c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.

Dokumenttyp:
journal article
Autor(en):
Deenick, EK; Po, L; Chapatte, L; Murakami, K; Lu, YC; Elford, AR; Saibil, SD; Ruland, J; Gerondakis, S; Mak, TW; Ohashi, PS
Abstract:
Elucidating the signaling events that promote T-cell tolerance versus activation provides important insights for manipulating immunity in vivo. Previous studies have suggested that the absence of PKCtheta results in the induction of anergy and that the balance between the induction of the transcription factors NFAT, AP1 and NF-kappaB plays a key role in determining whether T-cell anergy or activation is induced. Here, we examine whether Bcl-10 and specific family members of NF-kappaB act downstr...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2010
Band / Volume:
40
Heft / Issue:
3
Seitenangaben Beitrag:
867-77
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19950170
Print-ISSN:
0014-2980
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik
 BibTeX