User: Guest  Login
Title:

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Wittlich, Michaela; Dudek, Michael; Böttcher, Jan P; Schanz, Oliver; Hegenbarth, Silke; Bopp, Tobias; Schmitt, Edgar; Kurts, Christian; Garbers, Christoph; Rose John, Stefan; Knolle, Percy A; Wohlleber, Dirk
Abstract:
Liver sinusoidal endothelial cells (LSECs) are prominent liver-resident antigen (cross-)presenting cells. LSEC cross-priming of naïve CD8 T cells does not require CD4 T cell help in contrast to priming by dendritic cells (DC) but leads to the formation of memory T cells that is preceded by transient Granzyme B (GzmB) expression. Here we provide evidence for a so far unrecognized CD4 T helper cell function in LSEC-induced CD8 T cell activation.Naïve CD8 T cells and differentiated T helper 1 (T1)...     »
Journal title abbreviation:
J Hepatol
Year:
2017
Journal volume:
66
Journal issue:
5
Pages contribution:
978-986
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jhep.2016.12.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28025060
Print-ISSN:
0168-8278
TUM Institution:
Roman Herzog Comprehensive Cancer Center
 BibTeX