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Title:

RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.

Document type:
Journal Article
Author(s):
Coch, Christoph; Stümpel, Jan Phillip; Lilien-Waldau, Vanessa; Wohlleber, Dirk; Kümmerer, Beate M; Bekeredjian-Ding, Isabelle; Kochs, Georg; Garbi, Natalio; Herberhold, Stephan; Schuberth-Wagner, Christine; Ludwig, Janos; Barchet, Winfried; Schlee, Martin; Hoerauf, Achim; Bootz, Friedrich; Staeheli, Peter; Hartmann, Gunther; Hartmann, Evelyn
Abstract:
Influenza A virus infection causes substantial morbidity and mortality in seasonal epidemic outbreaks, and more efficient treatments are urgently needed. Innate immune sensing of viral nucleic acids stimulates antiviral immunity, including cell-autonomous antiviral defense mechanisms that restrict viral replication. RNA oligonucleotide ligands that potently activate the cytoplasmic helicase retinoic-acid-inducible gene I (RIG-I) are promising candidates for the development of new antiviral thera...     »
Journal title abbreviation:
Mol Ther
Year:
2017
Journal volume:
25
Journal issue:
9
Pages contribution:
2093-2103
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ymthe.2017.07.003
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28760668
Print-ISSN:
1525-0016
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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