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Title:

c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.

Document type:
journal article
Author(s):
Deenick, EK; Po, L; Chapatte, L; Murakami, K; Lu, YC; Elford, AR; Saibil, SD; Ruland, J; Gerondakis, S; Mak, TW; Ohashi, PS
Abstract:
Elucidating the signaling events that promote T-cell tolerance versus activation provides important insights for manipulating immunity in vivo. Previous studies have suggested that the absence of PKCtheta results in the induction of anergy and that the balance between the induction of the transcription factors NFAT, AP1 and NF-kappaB plays a key role in determining whether T-cell anergy or activation is induced. Here, we examine whether Bcl-10 and specific family members of NF-kappaB act downstr...     »
Journal title abbreviation:
Eur J Immunol
Year:
2010
Journal volume:
40
Journal issue:
3
Pages contribution:
867-77
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19950170
Print-ISSN:
0014-2980
TUM Institution:
III. Medizinische Klinik und Poliklinik
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