Benutzer: Gast  Login
Titel:

SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Griewahn, Laura; Müller-Foxworth, Madeleine; Peintner, Lukas; Wissler, Manuela; Weiss, Martina; Brauns-Schubert, Prisca; Massoumi, Ramin; Borner, Christoph; Groß, Olaf; Yabal, Monica; Charvet, Céline; Maurer, Ulrich
Abstract:
SPATA2 mediates the recruitment of CYLD to immune receptor complexes by bridging the interaction of CYLD with the linear ubiquitylation assembly complex (LUBAC) component HOIP. Whether SPATA2 exhibits functions independently of CYLD is unclear. Here, we show that, while Cyld-/- and Spata2-/- mice are viable, double mutants exhibit highly penetrant perinatal lethality, indicating independent functions of SPATA2 and CYLD. Cyld-/-Spata2-/- fibroblasts show increased M1-linked TNFR1-SC ubiquitylatio...     »
Zeitschriftentitel:
Cell Rep
Jahr:
2023
Band / Volume:
42
Heft / Issue:
1
Volltext / DOI:
doi:10.1016/j.celrep.2022.111961
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36640323
Print-ISSN:
2211-1247
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
 BibTeX