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Title:

TCF1 hepatitis C virus-specific CD8 T cells are maintained after cessation of chronic antigen stimulation.

Document type:
Journal Article
Author(s):
Wieland, Dominik; Kemming, Janine; Schuch, Anita; Emmerich, Florian; Knolle, Percy; Neumann-Haefelin, Christoph; Held, Werner; Zehn, Dietmar; Hofmann, Maike; Thimme, Robert
Abstract:
Differentiation and fate of virus-specific CD8 T cells after cessation of chronic antigen stimulation is unclear. Here we show that a TCF1CD127PD1 hepatitis C virus (HCV)-specific CD8 T-cell subset exists in chronically infected patients with phenotypic features of T-cell exhaustion and memory, both before and after treatment with direct acting antiviral (DAA) agents. This subset is maintained during, and for a long duration after, HCV elimination. After antigen re-challenge the less differentia...     »
Journal title abbreviation:
Nat Commun
Year:
2017
Journal volume:
8
Pages contribution:
15050
Language:
eng
Fulltext / DOI:
doi:10.1038/ncomms15050
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28466857
Print-ISSN:
2041-1723
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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