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Title:

NK cells with tissue-resident traits shape response to immunotherapy by inducing adaptive antitumor immunity.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Author(s):
Kirchhammer, Nicole; Trefny, Marcel P; Natoli, Marina; Brücher, Dominik; Smith, Sheena N; Werner, Franziska; Koch, Victoria; Schreiner, David; Bartoszek, Ewelina; Buchi, Mélanie; Schmid, Markus; Breu, Daniel; Hartmann, K Patricia; Zaytseva, Polina; Thommen, Daniela S; Läubli, Heinz; Böttcher, Jan P; Stanczak, Michal A; Kashyap, Abhishek S; Plückthun, Andreas; Zippelius, Alfred
Abstract:
T cell-directed cancer immunotherapy often fails to generate lasting tumor control. Harnessing additional effectors of the immune response against tumors may strengthen the clinical benefit of immunotherapies. Here, we demonstrate that therapeutic targeting of the interferon-γ (IFN-γ)-interleukin-12 (IL-12) pathway relies on the ability of a population of natural killer (NK) cells with tissue-resident traits to orchestrate an antitumor microenvironment. In particular, we used an engineered adeno...     »
Journal title abbreviation:
Sci Transl Med
Year:
2022
Journal volume:
14
Journal issue:
653
Fulltext / DOI:
doi:10.1126/scitranslmed.abm9043
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35857639
Print-ISSN:
1946-6234
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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