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Titel:

A single charge in the actin binding domain of fascin can independently tune the linear and non-linear response of an actin bundle network

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Maier, M.; Müller, K. W.; Heussinger, C.; Köhler, S.; Wall, W. A.; Bausch, A. R.; Lieleg, O.
Abstract:
Actin binding proteins ( ABPs) not only set the structure of actin filament assemblies but also mediate the frequency-dependent viscoelastic moduli of cross-linked and bundled actin networks. Point mutations in the actin binding domain of those ABPs can tune the association and dissociation dynamics of the actin/ABP bond and thus modulate the network mechanics both in the linear and non-linear response regime. We here demonstrate how the exchange of a single charged amino acid in the actin bindi...     »
Stichworte:
actin network, ABPs, viscoelastic modulation
Dewey Dezimalklassifikation:
530 Physik
Zeitschriftentitel:
Eur. Phys. J. E
Jahr:
2015
Band / Volume:
38
Heft / Issue:
5
Nachgewiesen in:
Web of Science
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1140/epje/i2015-15050-3
WWW:
http://link.springer.com/article/10.1140%2Fepje%2Fi2015-15050-3
Verlag / Institution:
Springer Science + Business Media
Publikationsdatum:
01.05.2015
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