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Title:

Osteopontin and `Melanoma Inhibitory Activity': Comparison of Two Serological Tumor Markers in Metastatic Uveal Melanoma Patients

Document type:
Zeitschriftenaufsatz
Author(s):
Haritoglou, Ingrid; Wolf, Armin; Maier, Tanja; Haritoglou, Christos; Hein, Rüdiger; Schaller, Ulrich Christoph
Abstract:
Background: Evaluation of the protein osteopontin (OPN) as a potential new marker in comparison to melanoma inhibitory activity (MIA) for screening and detection of metastatic uveal melanoma. Methods: Plasma levels of 32 patients with uveal melanoma were analyzed for OPN and MIA by enzyme-linked immunosorbent assay (ELISA). Fourteen of these patients had clinically detectable liver metastases. Results: Median plasma concentration of OPN in patients with metastatic disease was 152.01 ng/ml compared to 47.39 ng/ml in patients without clinically detectable metastases (p < 0.001). The difference between the median MIA plasma levels in patients with (13.11 ng/ml) and patients without (5.64 ng/ml) metastatic disease was also statistically significant (p < 0.001). No correlation could be found between MIA or OPN levels and tumor height in patients without clinically detectable metastases. Conclusion: The proteins MIA and OPN seem to be promising tumor markers for the metastasis screening in patients with uveal melanoma.
Keywords:
Uveal melanoma; Metastases; Osteopontin; Melanoma inhibitory activity; Serological marker
Journal title:
Ophthalmologica
Year:
2009
Journal volume:
223
Journal issue:
4
Pages contribution:
239--243
Fulltext / DOI:
doi:10.1159/000206139
Publisher:
S. Karger AG
Publisher address:
Basel, Switzerland
Print-ISSN:
1423-0267
E-ISSN:
1423-0267
Notes:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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