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Title:

Progress in the Use of Adeno-Associated Viral Vectors for Gene Therapy

Document type:
Zeitschriftenaufsatz
Author(s):
Büning, Hildegard; Braun-Falco, Markus; Hallek, Michael
Abstract:
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the parvovirus family. The advantages of this vector system is the stability of the viral capsid, the low immunogenicity, the ability to transduce both dividing and non-dividing cells, the potential to integrate site specifically and to achieve long-term gen...     »
Keywords:
Adeno-associated virus; Epidermis; Genodermatosis; Wound healing
Journal title:
Cells Tissues Organs
Year:
2004
Journal volume:
177
Journal issue:
3
Pages contribution:
139--150
Fulltext / DOI:
doi:10.1159/000079988
Publisher:
S. Karger AG
Publisher address:
Basel, Switzerland
Print-ISSN:
1422-6421
E-ISSN:
1422-6421
Notes:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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