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Titel:

Paclitaxel in the Neoadjuvant Treatment for Adeno carcinoma of the Distal Esophagus (AEG I). A Comparison of Two Phase II Trials with Long-Term Follow-Up

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Bader, Franz G.; Lordick, Florian; Fink, Ulrich; Becker, Karen; Höfler, Heinz; Busch, Raymonde; Siewert, Jörg; Ott, Katja
Abstract:
Introduction: We report a comparative analysis of 2 sequential, prospective phase II trials on the efficacy of platinum/leucovorin/5-fluorouracil (PLF) +/– paclitaxel (T-PLF) in the neoadjuvant treatment of adenocarcinoma of the esophagus (AEG I). Patients and Methods: Inclusion criteria were histologically proven, locally advanced AEG I stage uT3/4 anyN cM0/M1a. 67 patients were treated with either PLF (n = 32) or T-PLF (n = 35). Paclitaxel (80 mg/m2) was added to PLF on days 1, 15, and 29. Pri...     »
Stichworte:
Paclitaxel; Adenocarcinoma of the esophagus; Neoadjuvant chemotherapy
Zeitschriftentitel:
Onkologie
Jahr:
2008
Band / Volume:
31
Heft / Issue:
7
Seitenangaben Beitrag:
366--372
Volltext / DOI:
doi:10.1159/000135515
Verlag / Institution:
S. Karger GmbH
Verlagsort:
Freiburg, Germany
Print-ISSN:
1423-0240
E-ISSN:
2296-5262
Hinweise:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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