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Titel:

Longitudinal Changes of Cerebral Glucose Metabolism in Semantic Dementia

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Diehl-Schmid, J.; Grimmer, T.; Drzezga, A.; Bornschein, S.; Perneczky, R.; Förstl, H.; Schwaiger, M.; Kurz, A.
Abstract:
Background: Semantic dementia (SD). Objective: To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral 18F-fluoro-2-desoxy-D-glucose positron emission tomography scanning (18F-FDG-PET). Methods: Eight patients with SD underwent 18F-FDG-PET at baseline and at re-examination in average 15 months later. Results: Compared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05). Conclusion: Subtle functional changes suffice to produce significant neuropsycho- logical deterioration.
Stichworte:
Positron emission tomography; Semantic dementia; Frontotemporal dementia; Follow-up; Glucose metabolism
Zeitschriftentitel:
Dementia and Geriatric Cognitive Disorders
Jahr:
2006
Band / Volume:
22
Heft / Issue:
4
Seitenangaben Beitrag:
346--351
Volltext / DOI:
doi:10.1159/000095624
Verlag / Institution:
S. Karger AG
Verlagsort:
Basel, Switzerland
Print-ISSN:
1421-9824
E-ISSN:
1421-9824
Hinweise:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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