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Titel:

ICOS: A New Costimulatory Ligand/Receptor Pair and Its Role in T-Cell Activion

Autor(en):
Richter, G.; Burdach, S.
Abstract:
The inducible costimulator (ICOS) is a new member of the CD28/CD152 receptor family that regulates T-cell activation and function. ICOS binds to a specific ligand on antigen-presenting cells (APC) and cells of the peripheral tissue different from the CD28/CD152 ligands CD80 and CD86. ICOS-L can be induced by inflammatory stimuli in peripheral tissue and on some APC, including monocytes, but is downregulated in B-cell and myeloid leukemia. ICOS-L delivers distinct signals to T cells, presumably i...     »
Zeitschriftentitel:
Onkologie
Jahr:
2004
Band / Volume:
27
Heft / Issue:
1
Seitenangaben Beitrag:
91--95
Volltext / DOI:
doi:10.1159/000075612
Verlag / Institution:
S. Karger GmbH
Verlagsort:
Freiburg, Germany
Print-ISSN:
1423-0240
E-ISSN:
2296-5262
Hinweise:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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