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Titel:

No Effect of Anti-Interleukin-5 Therapy (Mepolizumab) on the Atopy Patch Test in Atopic Dermatitis Patients

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Oldhoff, J. M.; Darsow, U.; Werfel, T.; Bihari, I. C.; Katzer, K.; Laifaoui, J.; Plötz, S.; Kapp, A.; Knol, E. F.; Bruijnzeel-Koomen, C.A.F.M.; Ring, J.; Bruin-Weller, M. S. de
Abstract:
Background: The atopy patch test (APT) is an in vivo model to study the induction of eczema by inhalant allergens in atopic dermatitis (AD) patients. Mepolizumab is a monoclonal antibody to interleukin-5, which reduces peripheral blood eosinophils. Previously, we reported that mepolizumab treatment did not result in clinical improvement in AD. The current study investigates the effect of mepolizumab therapy on the APT in the same patients. Methods: Mepolizumab treatment was given at days 0 and 7...     »
Stichworte:
Anti-interleukin-5 antibody; Atopic dermatitis; Atopy patch test; Eosinophils; Mepolizumab; Skin biopsies
Zeitschriftentitel:
International Archives of Allergy and Immunology
Jahr:
2006
Band / Volume:
141
Heft / Issue:
3
Seitenangaben Beitrag:
290--294
Volltext / DOI:
doi:10.1159/000095299
Verlag / Institution:
S. Karger AG
Verlagsort:
Basel, Switzerland
Print-ISSN:
1423-0097
E-ISSN:
1423-0097
Hinweise:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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