Dissolution dynamic nuclear polarization enables real-time non-invasive measurement of metabolic fluxes using magnetic resonance spectroscopy. Quantitative kinetic information of in vivo metabolism is of great interest for medicine as a key characteristic of some diseases. In this work, comprehensive methods for the data acquisition, quantification, interpretation and visualization of dynamic
13C metabolite signals in vitro and in vivo were developed using the example of hyperpolarized [1-
13C]pyruvate
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Dissolution dynamic nuclear polarization enables real-time non-invasive measurement of metabolic fluxes using magnetic resonance spectroscopy. Quantitative kinetic information of in vivo metabolism is of great interest for medicine as a key characteristic of some diseases. In this work, comprehensive methods for the data acquisition, quantification, interpretation and visualization of dynamic
13C metabolite signals in vitro and in vivo were developed using the example of hyperpolarized [1-
13C]py...
»