Helicobacter infections are frequently associated with pathology in the host. Most Helicobacter species possess gamma-glutamyl transpeptidase (gGT), a possible virulence factor. gGT is an enzyme essential for colonization of the gastric mucosa in H. pylori infections and is correlated with a higher risk of peptic ulcer disease. In H. bilis, an enterohepatic bacterium associated with IBD and colitis, little is known about the function of this enzyme. In the present study, H.pylori and H.bilis gGT were shown to be implicated in activation of oxidative stress response cascades and the generation of a pro-inflammatory milieu by epithelial cells.     «

Helicobacter infections are frequently associated with pathology in the host. Most Helicobacter species possess gamma-glutamyl transpeptidase (gGT), a possible virulence factor. gGT is an enzyme essential for colonization of the gastric mucosa in H. pylori infections and is correlated with a higher risk of peptic ulcer disease. In H. bilis, an enterohepatic bacterium associated with IBD and colitis, little is known about the function of this enzyme. In the present study, H.pylori and H.bilis gGT...     »