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Title:

A pH-stable, mucin based nanoparticle system for the co-delivery of hydrophobic and hydrophilic drugs

Document type:
Zeitschriftenaufsatz
Author(s):
Lutz, Theresa M.; Kimna, Ceren; Lieleg, Oliver
Abstract:
Biopolymer-based drug carriers are commonly used for the development of safe delivery systems. However, biopolymer-based systems are often highly sensitive to the acidic pH levels in the stomach and release most of their cargo before they have reached their point of destination. Such premature drug release combined with the resulting high dose requirements is not cost-efficient and comes with the risk of unwanted side effects on non-target tissues/organs. This problem can be mitigated by the muc...     »
Keywords:
Glycoprotein; Hesperidin; Swelling; β-Carotene
Dewey Decimal Classification:
500 Naturwissenschaften
Journal title:
International Journal of Biological Macromolecules
Year:
2022
Journal volume:
215
Pages contribution:
102-112
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1016/j.ijbiomac.2022.06.081
Publisher:
Elsevier BV
E-ISSN:
0141-8130
Date of publication:
01.08.2022
TUM Institution:
Fachgebiet für Biomechanik, MW
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