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Title:

Contamination with Black Carbon Nanoparticles Alters the Selective Permeability of Mucin Hydrogels: Implications for Molecular Transport across Mucosal Barriers

Document type:
Zeitschriftenaufsatz
Author(s):
Marczynski, Matthias; Lutz, Theresa M.; Schlatterer, Rebecca; Henkel, Manuel; Balzer, Bizan N.; Lieleg, Oliver
Abstract:
Mucus is a complex hydrogel biomaterial whose composition is regulated meticulously to ensure that its important function as a selective barrier is maintained. As part of this function, mucus regulates the uptake of molecules from the gastrointestinal lumen into the body. Yet, those hydrogels are continuously challenged with environmental pollutants such as black carbon nanoparticles (NPs), and there is growing evidence that these contaminants can compromise the functionality of mucus. Here, we...     »
Keywords:
electrostatic interactions; mucus; nanoparticles; particulate matter; partitioning; translocation
Dewey Decimal Classification:
500 Naturwissenschaften
Journal title:
ACS Applied Nano Materials
Year:
2022
Journal volume:
5
Journal issue:
11
Pages contribution:
16955-16970
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1021/acsanm.2c03887
WWW:
https://www.scopus.com/record/display.uri?eid=2-s2.0-85141969609&origin=resultslist&zone=contextBox
Publisher:
American Chemical Society (ACS)
E-ISSN:
2574-09702574-0970
Date of publication:
11.11.2022
TUM Institution:
Fachgebiet für Biomechanik, MW
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