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Document type:
Zeitschriftenaufsatz 
Author(s):
Walstab, J.; Kruger, D.; Stark, T.; Hofmann, T.; Demir, I. E.; Ceyhan, G. O.; Feistel, B.; Schemann, M.; Niesler, B. 
Title:
Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-{HT}3 receptors of enteric neurons. 
Abstract:
BACKGROUND: Beneficial effects of ginger in the treatment of gastrointestinal (GI) problems and chemotherapy-induced nausea and vomiting are well accepted. In rodents, the action of ginger seems to be mediated by the inhibition of 5-HT3 receptors, which are established targets to combat emesis and irritable bowel syndrome. METHODS: Heterologously expressed human 5-HT3 A or 5-HT3 AB receptors were characterized by means of Ca(2+) influx studies using HEK293 cells. Complementing Ca(2+) measuremen...    »
 
Keywords:
Humans, HEK293 Cells, Plant Extracts/*pharmacology, Catechols/*pharmacology, Fatty Alcohols/*pharmacology, Ginger/chemistry, Neurons/*drug effects/metabolism, Receptors, Serotonin, 5-HT3/metabolism, Recombinant Proteins/metabolism, Serotonin 5-HT3 Receptor Antagonists/*pharmacology, Submucous Plexus/*drug effects/metabolism 
Journal title:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 
Year:
2013 
Journal volume:
25 
Month:
may 
Journal issue:
Pages contribution:
439--447, e302 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1365-2982 1350-1925