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Document type:
Zeitschriftenaufsatz 
Author(s):
Schwarz, Christoph; Tiessen, Christine; Kreutzer, Martin; Stark, Timo; Hofmann, Thomas; Marko, Doris 
Title:
Characterization of a genotoxic impact compound in Alternaria alternata infested rice as Altertoxin II 
Abstract:
Toxicity-guided fractionation was used to identify DNA strand breaking impact compounds in extracts obtained from rice heavily infested with the Alternaria alternata strains DSM 62006 and DSM 62010. The major genotoxic potential measured in the comet assay using human colon carcinoma cells (HT29) could be attributed to three unknown peaks, whereas the fractions containing alternariol, its monomethylether or tenuazonic acid showed no significant DNA damaging effects. According to (1)H and (13)C-N...    »
 
Journal title:
Archives of Toxicology 
Year:
2012 
Journal volume:
86 
Journal issue:
12 
Pages contribution:
1911--1925 
Print-ISSN:
0340-5761