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Title:

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.

Document type:
Journal Article
Author(s):
Heider, Michael; Eichner, Ruth; Stroh, Jacob; Morath, Volker; Kuisl, Anna; Zecha, Jana; Lawatscheck, Jannis; Baek, Kheewoong; Garz, Anne-Kathrin; Rudelius, Martina; Deuschle, Friedrich-Christian; Keller, Ulrich; Lemeer, Simone; Verbeek, Mareike; Götze, Katharina S; Skerra, Arne; Weber, Wolfgang A; Buchner, Johannes; Schulman, Brenda A; Kuster, Bernhard; Fernández-Sáiz, Vanesa; Bassermann, Florian
Abstract:
The complex architecture of transmembrane proteins requires quality control (QC) of folding, membrane positioning, and trafficking as prerequisites for cellular homeostasis and intercellular communication. However, it has remained unclear whether transmembrane protein-specific QC hubs exist. Here we identify cereblon (CRBN), the target of immunomodulatory drugs (IMiDs), as a co-chaperone that specifically determines chaperone activity of HSP90 toward transmembrane proteins by means of counteract...     »
Journal title abbreviation:
Mol Cell
Year:
2021
Journal volume:
81
Journal issue:
6
Pages contribution:
1170-1186.e10
Fulltext / DOI:
doi:10.1016/j.molcel.2020.12.046
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33571422
Print-ISSN:
1097-2765
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Klinik und Poliklinik für Nuklearmedizin
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