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Titel:

Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Jin, Kelly; Wilson, Kenneth A.; Beck, Jennifer N.; Nelson, Christopher S.; Brownridge, George W.; Harrison, Benjamin R.; Djukovic, Danijel; Raftery, Daniel; Brem, Rachel B.; Yu, Shiqing; Drton, Mathias; Shojaie, Ali; Kapahi, Pankaj; Promislow, Daniel
Abstract:
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found that genotypes within the same species vary widely in how they respond to DR. To explore the mechanisms underlying this variation, we exposed 178 inbred Drosophila melanogaster lines to a DR or ad libitum (AL) diet, and measured a panel of 105 metabolites under both diets. Twenty four out of 105 metabolites were associated with the magnitude of the lifespan response. These included proteinogenic a...     »
Dewey Dezimalklassifikation:
510 Mathematik
Zeitschriftentitel:
PLOS Genetics
Jahr:
2020
Band / Volume:
16
Jahr / Monat:
2020-07
Quartal:
3. Quartal
Monat:
Jul
Heft / Issue:
7
Seitenangaben Beitrag:
e1008835
Sprache:
en
Volltext / DOI:
doi:10.1371/journal.pgen.1008835
WWW:
PLOS Genetics
Verlag / Institution:
Public Library of Science (PLoS)
Print-ISSN:
1553-7390
E-ISSN:
1553-7404
Eingereicht (bei Zeitschrift):
08.01.2020
Angenommen (von Zeitschrift):
06.05.2020
Publikationsdatum:
09.07.2020
Semester:
SS 20
TUM Einrichtung:
Lehrstuhl für Mathematische Statistik
Format:
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