Liquid-liquid chromatography, a preparative separation method well-suited to natural compounds, uses the two liquid phases of a biphasic solvent system as the mobile and stationary phases. This work explores trapping multiple dual mode as an alternative operating mode for the separation of intermediately-eluting target components from (pseudo-)ternary mixtures. A model-based approach for operating parameter selection under maximized throughput conditions is developed and applied to both model and real mixtures, as well as implemented in a comparison study.
«
Liquid-liquid chromatography, a preparative separation method well-suited to natural compounds, uses the two liquid phases of a biphasic solvent system as the mobile and stationary phases. This work explores trapping multiple dual mode as an alternative operating mode for the separation of intermediately-eluting target components from (pseudo-)ternary mixtures. A model-based approach for operating parameter selection under maximized throughput conditions is developed and applied to both model an...
»