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Title:

Transforming Boolean models to continuous models: Methodology and application to T-cell receptor signaling

Author(s):
Wittmann, D. M.; Krumsiek, J.; Saez-Rodriguez, J.; Lauffenburg, D. A.; Klam, S.; Theis, F. J.
Abstract:
The understanding of regulatory and signaling networks has long been a core objective in Systems Biology. Knowledge about these networks is mainly of qualitative nature, which allows the construction of Boolean models, where the state of a component is either ' off' or ' on' . While often able to capture the essential behavior of a network, these models can never reproduce detailed time courses of concentration levels. Nowadays however, experiments yield more and more quantitative data. An obvi...     »
Journal title:
BMC Syst. Biol.
Year:
2009
Journal volume:
3
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