Benutzer: Gast  Login
Dokumenttyp:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Autor(en):
Yeo, Leonard Leong-Litt; Chen, Vanessa Hui En; Leow, Aloysius Sheng-Ting; Meyer, Lukas; Fiehler, Jens; Tu, Tian-Ming; Tham, Carol Huilian; Sia, Ching-Hui; Jamous, Ala; Behme, Daniel; Kastrup, Andreas; Papanagiotou, Panagiotis; Styczen, Hanna; Forsting, Michael; Lee, Tsong-Hai; Chu, Chan-Lin; Fischer, Sebastian; Maus, Volker; Abdullayev, Nuran; Kabbasch, Christoph; Mönch, Sebastian; Maegerlein, Christian; Arnberg, Fabian; Andersson, Tommy; Holmin, Staffan; Teoh, Hock-Luen; Paliwal, Prakash; Ahmad...     »
Titel:
Outcomes in young adults with acute ischemic stroke undergoing endovascular thrombectomy: A real-world multicenter experience.
Abstract:
Endovascular thrombectomy (EVT) is the standard of care for anterior circulation acute ischemic stroke (AIS) with large vessel occlusion (LVO). Young patients with AIS-LVO have distinctly different underlying stroke mechanisms and etiologies. Much is unknown about the safety and efficacy of EVT in this population of young AIS-LVO patients. All consecutive AIS-LVO patients aged 50 years and below were included in this multicenter cohort study. The primary outcome measured was functional recovery at 90 days, with modified Rankin Scale of 0-2 deemed as good functional outcome. A total of 275 AIS-LVO patients that underwent EVT from 10 tertiary centers in Germany, Sweden, Singapore, and Taiwan were included. Successful reperfusion was achieved in 85.1% (234/275). Good functional outcomes were achieved in 66.0% (182/275). Arterial dissection was the most prevalent stroke etiology (42/195, 21.5%). National Institutes of Health Stroke Scale (NIHSS) score at presentation was inversely related to good functional outcomes (aOR: 0.92, 95% CI: 0.88-0.96 per point increase, p < 0.001). Successful reperfusion (aOR: 3.22, 95% CI: 1.44-7.21, p = 0.005), higher ASPECTS (aOR: 1.21, 95% CI: 1.01-1.44, p = 0.036), and bridging intravenous thrombolysis (aOR: 2.37, 95% CI: 1.29-4.34, p = 0.005) independently predicted good functional outcomes. Successful reperfusion was inversely associated with in-hospital mortality (aOR: 0.14, 95% CI: 0.03-0.57, p = 0.006). History of hypertension strongly predicted in-hospital mortality (aOR: 4.59, 95% CI: 1.10-19.13, p = 0.036). While differences in functional outcomes exist across varying stroke aetiologies, high rates of successful reperfusion and good outcomes are generally achieved in young AIS-LVO patients undergoing EVT.
Zeitschriftentitel:
Eur J Neurol
Jahr:
2021
Band / Volume:
28
Heft / Issue:
8
Seitenangaben Beitrag:
2736-2744
Volltext / DOI:
doi:10.1111/ene.14899
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33960072
Print-ISSN:
1351-5101
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
 BibTeX