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Document type:
Zeitschriftenaufsatz 
Author(s):
Yucel, Sara Suna; Stelzer, Walter; Lorenzoni, Alessandra; Wozny, Manfred; Langosch, Dieter; Lemberg, Marius K 
Title:
The metastable XBP1u transmembrane domain defines determinants for intramembrane proteolysis by signal peptide peptidase 
Abstract:
Unspliced XBP1 mRNA encodes XBP1u, the transcriptionally inert variant of the unfolded protein response (UPR) transcription factor XBP1s. XBP1u targets its mRNA-ribosome-nascent-chain-complex to the endoplasmic reticulum (ER) to facilitate UPR activation and prevents overactivation. Yet, its membrane association is controversial. Here, we use cell-free translocation and cellular assays to define a moderately hydrophobic stretch in XBP1u that is sufficient to mediate insertion into the ER membran...    »
 
Journal title:
bioRxiv 
Year:
2018 
Fulltext / DOI: