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- Titel:
Effects of acute exercise on miRNA expression in coronary artery disease patients
- Dokumenttyp:
- Konferenzbeitrag
- Art des Konferenzbeitrags:
- Poster
- Autor(en):
- Mayr B, Mueller EE, Schaefer C, Droese S, Schoenfelder M, Niebauer J
- Seitenangaben Beitrag:
- 15
- Abstract:
- Background: Micro ribonucleic acids (miRNAs) are small non-coding RNA molecules that control gene expression by translational inhibition in health and disease. Exercise has been shown to affect expression of several miRNAs in healthy subjects, but this has not yet been studied in patients with coronary artery disease (CAD). Therefore, we set out to assess miRNA expression in response to acute all-out exercise in both healthy subjects and patients with CAD of both sexes. Methods: In this study, 20 CAD patients (10 males; 10 female) performed an all-out cycle ergometry. Total RNA was extracted from blood drawn before and 5 min after exercise. Each plasma sample was analyzed by quantitative reverse transcription polymerase chain reaction for a set of 187 target miRNAs that are known to be associated with endothelial function/dysfunction, cardiovascular, myocardial infarction and sudden cardiac death. Results: In response to all-out exercise, 57 miRNAs changed their expression levels (all p<0.05). These miRNAs are known to interact with HIF-1 (oxygen homeostasis); AMPK (cellular energy homeostasis); PI3K-Akt (regulation of cell cycle, metabolism, angiogenesis); and FoxO (glucose metabolism, oxidative stress). Also, 14 of these miRNA were differently expressed in men and women (p<0.05). I n relation to performance data, we could show that only miR-423-5p revealed a significant positive correlation with exercise capacity (R=0.561, p=0.01). Using multi variance analysis 9 miRNAs (let-7e-5p; miR-1; miR-19b-1-5p; miR-103a-3p; miR-148b-3p; miR-181b-5p; miR-188-5p; miR-423-5p; miR-874–3p) showed significantly different response to exercise between genders. Conclusions: We described for the first time, that miRNA expression changes after all-out exercise in coronary artery disease patients. Affected were miRNAs that are associated among others with glucose metabolism, oxidative stress, and angiogenesis. Future studies may wish to assess whether disease specific miRNA expression in response to exercise might serve as marker for patient outcome.
- Dewey-Dezimalklassifikation:
- 570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit; 790 Sport, Spiele, Unterhaltung
- Kongress- / Buchtitel:
- Jahrestagung 2018 der Österreichischen Kardiologischen Gesellschaft
- Band / Teilband / Volume:
- Volume 130, Issue 2 Supplement
- Ausrichter der Konferenz:
- Österreichische Kardiologische Gesellschaft
- Datum der Konferenz:
- 06.-09.06.2018
- Verlag / Institution:
- Springer
- Jahr:
- 2018
- Quartal:
- 2. Quartal
- Jahr / Monat:
- 2018-06
- Monat:
- Jun
- Seiten:
- 1
- Serientitel:
- Wiener klinische Wochenschrift
- Serienbandnummer:
- 130
- Serien-ISSN:
- 0043-5325
- Impact Factor:
- 0,963
- Reviewed:
- ja
- Sprache:
- en
- WWW:
- https://link.springer.com/journal/508/130/2/suppl/page/1%25252520
- Semester:
- SS 18
- TUM Einrichtung:
- Sportbiologie
BibTeX
Vorkommen:
- mediaTUM GesamtbestandHochschulbibliographie2018FakultätenSport- und GesundheitswissenschaftenLehrstuhl für Sportbiologie (Prof. Wackerhage)
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsHealth and Sport SciencesProfessur für Sportbiologie (Prof. Wackerhage)