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Original title:
Prediction and analysis of microRNAs and their targets in eukaryotic genomes
Translated title:
Vorhersage und Analyse von microRNAs und deren Bindestellen in eukaryotischen Genomen
Author:
Sturm, Martin
Year:
2010
Document type:
Dissertation
Institution:
Fakultät Wissenschaftszentrum Weihenstephan
Advisor:
Frischmann, Dimitri (Prof. Dr.)
Referee:
Frischmann, Dimitri (Prof. Dr.); Mewes, Hans-Werner (Prof. Dr.)
Language:
en
Subject group:
BIO Biowissenschaften
Keywords:
microRNA, Machine Learning, target sites, prediction
Translated keywords:
microRNA, Machine Learning, target sites, prediction
Abstract:
MicroRNAs are ~22 nucleotide long RNA molecules. They play a critical role in eukaryotic gene regulation by binding to the mRNA of protein coding genes mediating posttranscriptional repression. In this work experimentally verified microRNAs and their binding sites were analyzed and thereon the machine learning based prediction tools MiRanalyzer (http://web.bioinformatics.cicbiogune.es/microRNA/) and TargetSpy (http://www.targetspy.org) were developed. The former enables the detection of known an...    »
Translated abstract:
MicroRNAs sind endogene ~22 Nukleotid lange RNA Moleküle. Sie spielen eine wichtige Rolle in der eukaryotischen Genregulation, indem sie durch Anlagerung an die mRNA proteinkodierender Gene posttranskriptionelle Repression bewirken. In dieser Arbeit wurden experimentell verifizierte microRNAs und deren Bindestellen analysiert und in Folge basierend auf Machine Learning die Vorhersageprogramme MiRanalyzer (http://web.bioinformatics.cicbiogune.es/microRNA/) und TargetSpy (http://www.targetspy.org)...    »
WWW:
https://mediatum.ub.tum.de/?id=963028
Date of submission:
16.02.2010
Oral examination:
21.07.2010
Pages:
119
Urn (citeable URL):
https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20100721-963028-1-0
Last change:
10.08.2010
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